Volume 20 No 12 (2022)
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Treatment of urinary tract infections that caused by Escherichia coli through the suggest fimH inhibitors from molecular docking approach
Alaa Abdul Razaq Alnuaimi , Mohammed Sabri Abdul Razzaq , Hassan M. Abo almaali
Escherichia coli are one of the most important organisms that cause urinary tract infection (UTI) in more than 95% of patients with UTI. This study aims to search for inhibitors of (fimH) by docking method using computer programs and websites specialized for this purpose. This study involved (63 samples) with positive E.coli was collected from patients with UTI during the period from February 2021 to October 2021, from an Iraqi hospital in Karbala. Full laboratory investigation for E.coli would be made to detect FimH and prediction suitable inhibitors. FimH was found in most E.coli isolates, it was found in 61(96.82%) of 63 samples. Chamomile appears to be a good FimH inhibitor, with a docking score of (-9.4), and can reduce UTI in roughly 50 percent of rats examined. Most pathogenic Type 1 fimbriae, which are hair-like appendages, can be expressed by E. coli strains. FimH protein starts out as a 300-amino-acid precursor before being transformed into a 279- amino-acid mature version. These fimbriae aid in the bacteria's colonization of numerous host tissues by mediating binding to D-mannose-containing structures. The chamomile was predicted as a suitable inhibitor of (fimH), and it was tested on rats. The results showed that it has a good inhibitory property; in addition to that, it is safe and has other benefits
E.coli, molecular docking, FimH, UPEC, urinary tract infection.
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