Volume 20 No 8 (2022)
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Versatile Properties and Biological Significance of Imidazole and Its Derivatives: A Comprehensive Mini Overview
Jagat Pal Yadav, Shubhrat Maheshwari, Ajeet Kumar, Alka, Neeraj Jain, Neelam Jain, Shailendra Singh Bhadauriya
Abstract
Imidazole holds a distinctive role in heterocyclic chemistry, garnering significant interest due to its diverse properties in both chemistry and pharmacology. This nitrogen-containing heterocyclic ring, characterized by the formula C3N2H4, stands as a pivotal organic compound. Its structure comprises a five-membered heterocyclic aromatic ring with two sp2 hybridized nitrogen atoms. The derivatives of imidazole have captured attention in recent years owing to their versatile nature in various fields, particularly in biology and pharmacology. Imidazole exhibits a spectrum of biological activities, ranging from antimicrobial and anti-tuberculosis properties to antihypertensive, antioxidant, anti-inflammatory, anticonvulsant, antidepressant, anticancer, and antifungal effects. Notably, imidazole demonstrates amphoteric behavior, functioning both as an acid and a base. It is classified within the azoles group, alongside compounds like ketoconazole, miconazole, and clotrimazole. Furthermore, within the azoles category, there exist triazoles such as fluconazole, itraconazole, and voriconazole, highlighting the broader classification within which imidazole resides.
Keywords
Imidazole, Antimicrobial, Antifungal, Aromatic compound.
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