Volume 20 No 10 (2022)
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WOUND HEALING POTENTIAL OF BACOPA MONNIERIIN ACID BURN & BOILING WATER INDUCED WOUNDS
Mohammad Asif Khan , Ramandeep Kaur , MohdRuman Khan , Varsha Singh , Nitin Mishra
Abstract
It is believed that people have employed herbal treatments since ancient times. There is a lot of potential for using plants to treat and control diseases. This study was based on screening of wound healing potential of hydroalcoholic leaves extract of BM in acid burn & boiling water induced wounds.Bacopa monnieri medicinal benefits are thought to be mediated by triterpenoid saponins found in the plant extract. Bacoside is the most versatile triterpenoid saponins. The fresh leaves of BM were collected and identified by the botanist at MJPRU Bareilly. Leaves washed thoroughly to make the object soil free and crushed into small pieces, weighed (20g). It was soaked into hydroalcoholic solution (1:1) for 15 days with frequent stirrings.Rats were divided into 5 groups; Group 1 was applied cream base, Group 2 applied Lobate GM, Group 3, 4 & 5 were applied BM leaves extract cream 20%, 50% and 100% respectively. Wound contraction, tissue epithelization period and hydroxyproline contents were evaluated. It resulted out that in both the acid burn and boiling water models, BM leaf extract showed a substantial ability to cure wounds. In conclusion, BM leaves extract significantly demonstrated wound healing potential in various screening protocols.It confirms that it can be incorporated into suitable dosage forms to use among human being and animals.
Keywords
Bacopa Monnieri leaves,hydroalcoholic, wound healing, acid burn, wound contraction
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