DOI: 10.14704/nq.2018.16.6.1587

Analysis of Genetic Factors in Children with Cerebral Palsy

Yinsen Song, Yinghui Zhang, PengBo Guo, Lili Ge, Bo Zhang, Lei Liu, Jingui Kong, Chongfen Chen, Shuying Luo

Abstract


Cerebral palsy is a group of permanent limb posture and movement abnormalities caused by certain injuries to fetal or neonatal brain before its growth and development is completed. It is reported abroad that the incidence of cerebral palsy in live births (including full-term and preterm infants) is about 1/500, which is the most common disability disease in children. Despite many epidemiological studies, the cause of the epidemic has not yet been identified, because cerebral palsy is a complex group of symptoms, rather than a simple disease which is usually diagnosed clinically around the age of one. Some severe complications during pregnancy, such as placental abruption, umbilical cord prolapse, and uterine rupture, significantly increase the risk of cerebral palsy, but in general these factors account for only a small proportion of cerebral palsy. At present, the major risk factors for cerebral palsy widely known at home and abroad are preterm infants, intrauterine infections or maternal fever at birth, ischemic stroke, congenital malformations, fetal intrauterine abnormal growth, and multiple pregnancies. In addition, a great deal of evidence suggests that although genetic factors are not the primary cause of cerebral palsy, they may increase genetic susceptibility to cerebral palsy. Any kind of pathogenic factor reaching a certain degree of severity may cause cerebral palsy. But more often than not, multiple risk factors jointly destroy the body's defense mechanism and eventually lead to cerebral palsy.

Keywords


Hereditary Diseases, Hereditary Thrombophilia, Preterm Infants, Cerebral Dysplasia, Congenital Metabolic Disorder.

Full Text:

PDF

References


Bodensteiner JB, Johnsen SD. Cerebellar injury in the extremely premature infant: newly recognized but relatively common outcome. Journal of Child Neurology 2005; 20(2): 139-42.

Feng GQ, Shang XP, Lin XZ. Analysis of clinical symptoms of cerebral palsy and head CT. Chinese Journal of Rehabilitation Theory and Practice 2001; 7(4): 170-73.

Gibbs RS. The reIationship between infection and adverse pregnancy outcomes: an overview. Annals of Periodontology 2001; 6(1): 153-63.

Hu YY. Development of the concept of cerebral palsy. Chinese Journal of Rehabilitation Theory and Practice 2003; 9(5): 257-58.

Jacobsson B, Hagberg G. Antenatal risk factors for cerebral palsy. Best Practice & Research Clinical Obstetrics & Gynaecology 2004; 18(3): 425-36.

Li S, Lin Q, Liu J. Prevalence of childhood cerebral palsy in six provinces in China. National Medical Journal of China 2001; 81(20): 1220-23.

Lin S, Xu JM, Sun J, Li CY. MRI features of periventricular leukomalacia in children with cerebral palsy. Chinese Journal of Rehabilitation Theory and Practice 2001; 7(1): 21-22.

Mutch LW, Alberman E, Hagberg B, Kodama K, Perat MV. Cerebral palsy epistemology: where are we now and where are we going. Developmental Medicine & Child Neurology 1992; 34: 547-55.

Nelson KB, Dambrosia JM, lovannisci DM, Cheng S, Grether JK, Lammer E. Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatric Research 2005; 57(4): 484-99.

Nelson KB. Causative factors in cerebral palsy. Clinical Obstetrics & Gynecology 2008; 15(1): 21-26.

Raiu TN, Nelson KB, Ferriero D, Lynch JK. Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Hu-man Development and the National Institute of Neurological Disorders and Stroke. Pediatrics 2007; 120(3): 609-16.

Schaefer GB. Genetics considerations in cerebral palsy. Seminars in Pediatric Neurology 2008; 15(1): 21-26.

Velickovic M. Treatment of cerebral palsy in the past, nowadays and in the future. Journal of Applied Clinical Pediatrics 2003; 18(3): 158-59.

Wang H. The Prevention research status of cerebral palsy. Chinese Journal of Rehabilitation Medicine 2004; 19(8): 637-40.

Xu ZC, Sun YJ, Gao WY. The value of auxiliary examination for diagnosis of pediatric cerebral palsy. Chinese Journal of Rehabilitation Theory and Practice 2002; 8(1): 34-35.

Zhang YL, Pan YQ. The diagnostic value of ventricular ultrasound in cerebral palsy. Chinese Journal of Practical Pediatrics 2000; 15(2): 108-10.

Zhong YQ, Wu J, Wu KM, Wen R, Hou G, Peng D, Li X, Shuai H, Xie X, Tao X, Zhou W. Evaluation of risk factors associated with cerebral palsy in children of Leshan Prefecture, Sichuan: a case control study on 308 cases. Chinese Journal of Preventive Medicine 2002; 36(5): 323-26.


Supporting Agencies





| NeuroScience + QuantumPhysics> NeuroQuantology :: Copyright 2001-2019