Natural products proved to be rich source of lead compounds for drug development. Ocean has numerous numbers of marine sources such as algae, fungi, sponges etc. Under competitive environments, marine sponges possess chemical richness and interesting biological activity of secondary metabolites. the current review paper highlights the marine sponges like Agelas, Aaptos, Psammaplysillapurea, lanthella basta, Verongiaaerophoba, spongosorites, Irciniaamphimedon etc., are focussed on their bioactivity and chemical richness. Agelaspongin family reported to have more alkaloid groups such as pyrrole, imidazole, terpenoid alkaloids which exhibits Cytotoxic, Antibacterial, Broad spectrum, Antimicrobial, Immunosuppressant activities. Relevant summaries on the marine source, its compounds, and associated bioactivity belonging to various chemical classes are also provided. This article would be beneficial for future research and development of new drugs from marine sponges.

Marine sponges, Algae, Alkaloids, Cytotoxicity, Antibacterial, Chemistry, Marine sources, Drug discovery