Volume 20 No 13 (2022)
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A systematic Review on Terpenes As Potential Antidiabetic Compounds
MarutiShelar, Roshani Paradh, Dr. Maruti K. Shelar
Abstract
Type -II diabetes is a major outbreak and fastest growing disease in this modern lifestyle society. A current treatment includes various oral hypoglycemics, insulin and balance diet rules. There is need of remedy to develop a plant-based drug for Type- II diabetes management. The present review introduces terpenes a plant secondary metabolite having significant antidiabetic activity. The study focused mainly on various pathways of terpenes acting as antidiabetic isolated from plants and tested in-vivo, in-vitro and Insilico. The Literature on terpenes showed antidiabetic activity were selected. This review summarizes the terpenes classification, various target of type- II diabetes, pathways of terpenes phytoconstituents for treatment of diabetes, Insilico studies on in-vivo targets and other clinical significance of terpenes responsible for producing a therapeutic effect in the management of diabetes.These secondary metabolites are have structural diversity which has significant curative potential against diabetes by lowering blood glucose level and inhibiting α-amylase, α- glucosidase enzymes and aldose reductase enzyme, and also suppresses other diabetic complications by antihyperlipidemic activity, antioxidant activity have been beneficial for management of Type -II diabetes. By the study terpenes are futuristic medicament and alternative in the management of Diabetes mellitus.
Keywords
Type-II Diabetes, Terpenes, pathways, in-vivo, in-vitro and Insilico
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