Thiazines are a group of heterocyclic organic compounds that are biological active compounds with different antimicrobial activities, CNS activity, and anti-cancer activity. In the literature, different methods for the synthesis of thiazine derivatives are available. In this article, we present a review of literature on the synthetic methods of various biologically active thiazine derivatives viz., synthesis of natural products containing thiazines, catalytic methods, and green synthesis and stereo-selective methods. Because of wide spread biological/pharmaceutical activities of thiazine derivatives, they play an important role in the treatment of various diseases. They are significantly active as anti-bacterial, anti-cancer agents anti-fungal, anti-neoplastic, anti-viral, anti-inflammatory, and anti-malarial. To this end as they represent an interesting class of heterocyclic compound it is important to explore further these derivatives for various applications

Green Synthesis, One-Pot Synthesis, Cycloadditions, Stereo-selective Synthesis, Biological activity