Drugs can stay in the stomach for several hours, extending the gastric residence period. It can be used to deliver local drugs to the stomach and proximal small intestine. Prolonged stomach retention improves bioavailability, decreases drug waste, and increases solubility. Gastroesophageal reflux disease, also known as acid reflux or GERD is a chronic ailment. 10mg of medication has been dissolved in 20ml of methanol. The wavelength from maximum absorption was 276.5nm when a standard solution of pantoprazole (10mg/ml) was scanned. The polymers HPMCK15M and PVP prolonged medication release from floating tablets. Pantoprazole was chosen for this study as it has a shorter biological half-life and better bioavailability. This issue can be remedied by developing a gastro-retentive drug delivery device. Finally, it was determined that among all formulations (F1-F12), formulation F4 demonstrated better buoyancy and dissolution profile prepared with HPMCK4M, HPMCK15M, and PVP slowed high regression values of 0.992 for zero order on the basis of observed and predicted value (Box bhenken design) with drug release in 6 hr, making it (F4) to be selected as optimised formulation when compared to other formulations. based on observed and anticipated value The polymers HPMCK15M and PVP aided in the prolonged release of the medication (pantoprazole) from the floating tablet.

GERD, HPMCK, PANTOPRAZOLE SODIUM, Bioavailability