Naratriptan Hydrochloride is a 5-hydroxytryptamine 1 receptor subtype agonist used to treat migraines. Naratriptan was purified using an RP-HPLC technique using a 25:75 v/v potassium dihydrogen phosphate (KH2PO4):acetonitrile mobile phase. The detecting wavelength was 224nm, and the flow rate was kept constant at 1.0 ml/min. The linearity of the suggested Naratriptan technique was tested in the 5-25mg/ml range. The quantitation limit was 0.75 mg/ml, and the detection limit was 0.25 mg/ml. The % recovery of nariptan ranged from 98.22 to 99.04. The percent R.S.D. value for intraday precision research was 1% and 2% for interday precision study, demonstrating that the procedure was exact enough. The validation investigations were conducted in compliance with ICH guidelines.The approach was discovered to be particular, linear, exact, accurate, and resilient

Naratriptan; HPLC; Assay, Migraine