Heteropoly acid (DTP/SiO2) Catalyzed Environmentally Benign Synthesis of 4-substituted-1,5-benzodiazepine Derivatives

Volume 20 No 9 (2022)

Dadabhau A. Kharat, Mazahar Farooqui, Madhav J. Hebade, Bhagwansing S. Dobhal

DOI: 10.14704/nq.2022.20.9.NQ44787

Abstract

A silica-supported dodecatungestophosphoric heteropoly acid (DTP/SiO2) promoted cyclocondensationcyclization pathway has been established using one pot reaction of benzene-1,2-diamine, 5,5- dimethylcyclohexane-1,3-dione and benzaldehyde, DTP/SiO2 (12 mol%) and 10 ml DMF to give 1,5- benzodiazepine derivatives in good to promising yields. Application for this protocol easy workup, high yields, short reaction times, variability of functional groups, recyclability and solvent-free conditions.

Keywords

Heteropoly acid (DTP/SiO2), Environmentally benign, Multicomponent reactions, 1,5- benzodiazepine

Copyright © Neuroquantology

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in the Neuroquantology are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJECSE right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.