The comprehension of the pathogenesis of schizophrenia finds a new impulse in studies on non- linear dynamics of EEG signals and in the growing genetic molecular evidence of the mitochondrial origin of this disease. These data are consistent with the information known by Quantum Biophysical Semeiotics, that clinically investigates microcirculation both on a functional (i.e., by studying its non-linear dynamics), and on a structural viewpoint. Mitochondrial and microcirculatory dysfunctions reflect those of a genetically altered mit-DNA and of a functional mitochondrial cytopathy known as Congenital Acidosic Enzyme-Metabolic Histangiopathy, originating from this mutation and which is particularly intense both in patients with schizophrenia and in those with Inherited Real Risk of this disorder. Preclinical diagnosis of Inherited Real Risk of schizophrenia presents the opportunity to examine subjects with a predisposition to this disease since birth in order to perform an efficient pre-primary and primary prevention

schizophrenia diagnosis, mitochondrial dysfunction, primary prevention, quantum therapy, deterministic chaos