Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic Effectiveness. Consequences of poor aqueous solubility would lead to failure in formulation development. The poor solubility of drug substances in water (less than 1µg/ml) and their low dissolution rate in aqueous G.I.T. fluid often leads to insufficient bioavailability. There are few methods to enhance aqueous solubility of poorly soluble drug among them solid dispersion is one of the effective and accepted technique in the pharmaceutical industry. Therefore, in this study attempt is done to improve the physicochemical properties of Luliconazole, a poorly water-soluble drug, by forming dispersion with PEG 6000 as water soluble carrier. The solid dispersions of Luliconazole: PEG 6000 were prepared in ratio 1:1, 1:2, 1:3, 1:4, 1:5, 1:6 and 1:7 w/w by melting and physical triturating method. The formulations were characterized for drug content, DSC, FTIR spectrum, XRD & % drug release studies by Franz Diffusion Cell. All the formulations showed marked improvement in the solubility behaviour and improve dissolution rate. Formulation containing drug: PEG 6000 ratio of 1:4 w/w showed the best release 83% in 60 min as compared to the pure drug i.e.,39 % in 60 min. The interaction studies showed no interaction between the drug and the carrier. It was concluded that PEG 6000 as a carrier can be well utilized to improve the solubility of poorly soluble drugs.

Luliconazole, PEG 6000, Solubility, Solid Dispersion, Franz Diffusion Cell, FTIR spectrum, XRD, DSC