A novel series of substitute imidazole derivatives were synthesized and their analgesic activity was evaluate using Eddyʼs hot plate method. In the first step, substituted amines were allowed to react with substituted benzaldehyde in an equimolar amount with glacial acetic acid to form various substituted Schiff’s base intermediate (1a-h). Schiff’s base on treatment with benzil in the presence of ammonium acetate afforded corresponding imidazole derivatives (2a-h). The structure of the final analogs has been confirmed on the basis of elemental analysis, fourier transform infrared spectroscopy (FT-IR), 1H nuclear magnetic resonance (NMR), 13C NMR, and mass spectra. The compound 2b and 2c was found to be most effective compound compared to the Diclofenac conventional drug. Eddyʼs hot plate method was utilized to evaluate the test compounds for their in vivo analgesic activity.

Imidazole, analgesic activity, Sciff base, Eddy hot plate.