Biomarkers are substances that are helpful for both diagnostic and prognostic purposes. Since diffuse infiltrating gliomas are difficult to treat, an earlier diagnosis using these biomarkers provide an earlier non-invasive method of diagnosis with an increase in survival rate. Several circulating tumor markers are available for gliomas which can be detected in blood as well as cerebrospinal fluid. A biomarker for a neoplasm could be a tumor cell, a normally or abnormally elaborated protein, nucleic acids or an enzyme specific to the cell of origin. In gliomas, these range from circulating tumor cells (CTCs), circulating tumor derived exosomes (CTdE), circulating tumor associated Nucleic acids (CNAs), circulating tumor associated proteins (CTaP) and biomarkers produced by tumor associated inflammatory cells. This review focusses on the various available biomarkers which serve as prognostic indicators in diffuse gliomas and glioblastomas

Glioma, Biomarkers, Tumor